Abolished ketamine effects on the spontaneous excitatory postsynaptic current of medial prefrontal cortex neurons in GluN2D knockout mice

Abstract Ketamine, a non-competitive antagonist of the N-methyl-d-aspartate receptor (NMDAR), generates a rapidly-acting antidepressant effect.It exerts psychomimetic effects, yet demands a further investigation of its mechanism.Previous research showed that ketamine did no longer promote hyperlocomotion in GluN2D knockout (KO) mice, which is a sub

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